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10.1172/JCI93940 http://scihub22266oqcxt.onion/10.1172/JCI93940 C5663355!5663355 !29035282     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29035282 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 2017 ; 127 (11 ): 4163-4178 Nephropedia Template TP {{tp|p=29035282 |t=2017. Endothelial transplantation rejuvenates aged hematopoietic stem cell function |pdf=|usr=}}{{29035282 }} gab.com Text Endothelial transplantation rejuvenates aged hematopoietic stem cell function JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=29035282 #FOAvip Age-related changes in the hematopoietic compartment are primarily attributed to cell-intrinsic alterations in hematopoietic stem cells (HSCs); however, the contribution of the aged microenvironment has not been adequately evaluated. Understanding the role of the bone marrow (BM) microenvironment in supporting HSC function may prove to be beneficial in treating age-related functional hematopoietic decline. Here, we determined that aging of endothelial cells (ECs), a critical component of the BM microenvironment, was sufficient to drive hematopoietic aging phenotypes in young HSCs. We used an ex vivo hematopoietic stem and progenitor cell/EC (HSPC/EC) coculture system as well as in vivo EC infusions following myelosuppressive injury in mice to demonstrate that aged ECs impair the repopulating activity of young HSCs and impart a myeloid bias. Conversely, young ECs restored the repopulating capacity of aged HSCs but were unable to reverse the intrinsic myeloid bias. Infusion of young, HSC-supportive BM ECs enhanced hematopoietic recovery following myelosuppressive injury and restored endogenous HSC function in aged mice. Coinfusion of young ECs augmented aged HSC engraftment and enhanced overall survival in lethally irradiated mice by mitigating damage to the BM vascular microenvironment. These data lay the groundwork for the exploration of EC therapies that can serve as adjuvant modalities to enhance HSC engraftment and accelerate hematopoietic recovery in the elderly population following myelosuppressive regimens. Twit Text FOAVip Endothelial transplantation rejuvenates aged hematopoietic stem cell function ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=29035282 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29035282 #FOAvip English Wikipedia <ref>{{Cite pmid|29035282 }}</ref> Endothelial transplantation rejuvenates aged hematopoietic stem cell function #MMPMID29035282 Poulos MG ; Ramalingam P ; Gutkin MC ; Llanos P ; Gilleran K ; Rabbany SY ; Butler JM J Clin Invest 2017[Nov]; 127 (11 ): 4163-4178 PMID29035282 show ga Age-related changes in the hematopoietic compartment are primarily attributed to cell-intrinsic alterations in hematopoietic stem cells (HSCs); however, the contribution of the aged microenvironment has not been adequately evaluated. Understanding the role of the bone marrow (BM) microenvironment in supporting HSC function may prove to be beneficial in treating age-related functional hematopoietic decline. Here, we determined that aging of endothelial cells (ECs), a critical component of the BM microenvironment, was sufficient to drive hematopoietic aging phenotypes in young HSCs. We used an ex vivo hematopoietic stem and progenitor cell/EC (HSPC/EC) coculture system as well as in vivo EC infusions following myelosuppressive injury in mice to demonstrate that aged ECs impair the repopulating activity of young HSCs and impart a myeloid bias. Conversely, young ECs restored the repopulating capacity of aged HSCs but were unable to reverse the intrinsic myeloid bias. Infusion of young, HSC-supportive BM ECs enhanced hematopoietic recovery following myelosuppressive injury and restored endogenous HSC function in aged mice. Coinfusion of young ECs augmented aged HSC engraftment and enhanced overall survival in lethally irradiated mice by mitigating damage to the BM vascular microenvironment. These data lay the groundwork for the exploration of EC therapies that can serve as adjuvant modalities to enhance HSC engraftment and accelerate hematopoietic recovery in the elderly population following myelosuppressive regimens. |*Hematopoiesis [MESH] |*Hematopoietic Stem Cell Transplantation [MESH] |Aging [MESH] |Animals [MESH] |Bone Marrow Transplantation [MESH] |Bone Marrow/blood supply [MESH] |Cells, Cultured [MESH] |Coculture Techniques [MESH] |Endothelial Cells/*physiology/transplantation [MESH] |Hematopoietic Stem Cells/*physiology [MESH] |Mice, Inbred C57BL [MESH] |Microvessels/pathology [MESH] |Radiation Injuries, Experimental/prevention & control [MESH]Endothelial transplantation rejuvenates aged hematopoietic stem cell f(epmc).pdf DeepDyve Pubget Overpricing