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2016 ; 37
(2
): 263-75
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Endothelial and Microcirculatory Function and Dysfunction in Sepsis
#MMPMID27229643
Colbert JF
; Schmidt EP
Clin Chest Med
2016[Jun]; 37
(2
): 263-75
PMID27229643
show ga
The microcirculation is a series of arterioles, capillaries, and venules that
performs essential functions of oxygen and nutrient delivery, customized to the
unique physiologic needs of the supplied organ. The homeostatic microcirculatory
response to infection can become harmful if overactive and/or dysregulated.
Pathologic microcirculatory dysfunction can be directly visualized by intravital
microscopy or indirectly measured via detection of circulating biomarkers.
Although several treatments have been shown to protect the microcirculation
during sepsis, they have not improved patient outcomes when applied
indiscriminately. Future outcomes-oriented studies are needed to test sepsis
therapeutics when personalized to a patient's microcirculatory dysfunction.