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10.1002/sctm.16-0360

http://scihub22266oqcxt.onion/10.1002/sctm.16-0360
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suck abstract from ncbi


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pmid28296182
      Stem+Cells+Transl+Med 2017 ; 6 (5 ): 1316-1320
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  • Endothelial Progenitors: A Consensus Statement on Nomenclature #MMPMID28296182
  • Medina RJ ; Barber CL ; Sabatier F ; Dignat-George F ; Melero-Martin JM ; Khosrotehrani K ; Ohneda O ; Randi AM ; Chan JKY ; Yamaguchi T ; Van Hinsbergh VWM ; Yoder MC ; Stitt AW
  • Stem Cells Transl Med 2017[May]; 6 (5 ): 1316-1320 PMID28296182 show ga
  • Endothelial progenitor cell (EPC) nomenclature remains ambiguous and there is a general lack of concordance in the stem cell field with many distinct cell subtypes continually grouped under the term "EPC." It would be highly advantageous to agree on standards to confirm an endothelial progenitor phenotype and this should include detailed immunophenotyping, potency assays, and clear separation from hematopoietic angiogenic cells which are not endothelial progenitors. In this review, we seek to discourage the indiscriminate use of "EPCs," and instead propose precise terminology based on defining cellular phenotype and function. Endothelial colony forming cells and myeloid angiogenic cells are examples of two distinct and well-defined cell types that have been considered EPCs because they both promote vascular repair, albeit by completely different mechanisms of action. It is acknowledged that scientific nomenclature should be a dynamic process driven by technological and conceptual advances; ergo the ongoing "EPC" nomenclature ought not to be permanent and should become more precise in the light of strong scientific evidence. This is especially important as these cells become recognized for their role in vascular repair in health and disease and, in some cases, progress toward use in cell therapy. Stem Cells Translational Medicine 2017;6:1316-1320.
  • |Animals [MESH]
  • |Cell- and Tissue-Based Therapy/methods [MESH]
  • |Endothelial Progenitor Cells/*cytology [MESH]
  • |Humans [MESH]
  • |Neovascularization, Physiologic/physiology [MESH]


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