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2017 ; 6
(5
): 1316-1320
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Endothelial Progenitors: A Consensus Statement on Nomenclature
#MMPMID28296182
Medina RJ
; Barber CL
; Sabatier F
; Dignat-George F
; Melero-Martin JM
; Khosrotehrani K
; Ohneda O
; Randi AM
; Chan JKY
; Yamaguchi T
; Van Hinsbergh VWM
; Yoder MC
; Stitt AW
Stem Cells Transl Med
2017[May]; 6
(5
): 1316-1320
PMID28296182
show ga
Endothelial progenitor cell (EPC) nomenclature remains ambiguous and there is a
general lack of concordance in the stem cell field with many distinct cell
subtypes continually grouped under the term "EPC." It would be highly
advantageous to agree on standards to confirm an endothelial progenitor phenotype
and this should include detailed immunophenotyping, potency assays, and clear
separation from hematopoietic angiogenic cells which are not endothelial
progenitors. In this review, we seek to discourage the indiscriminate use of
"EPCs," and instead propose precise terminology based on defining cellular
phenotype and function. Endothelial colony forming cells and myeloid angiogenic
cells are examples of two distinct and well-defined cell types that have been
considered EPCs because they both promote vascular repair, albeit by completely
different mechanisms of action. It is acknowledged that scientific nomenclature
should be a dynamic process driven by technological and conceptual advances; ergo
the ongoing "EPC" nomenclature ought not to be permanent and should become more
precise in the light of strong scientific evidence. This is especially important
as these cells become recognized for their role in vascular repair in health and
disease and, in some cases, progress toward use in cell therapy. Stem Cells
Translational Medicine 2017;6:1316-1320.