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Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis
#MMPMID27122657
Yang X
; Chang Y
; Wei W
Mediators Inflamm
2016[]; 2016
(?): 6813016
PMID27122657
show ga
Inflammation, as a feature of rheumatoid arthritis (RA), leads to the activation
of endothelial cells (ECs). Activated ECs induce atherosclerosis through an
increased expression of leukocyte adhesion molecules. Endothelial dysfunction
(ED) is recognized as a failure of endothelial repair mechanisms. It is also an
early preclinical marker of atherosclerosis and is commonly found in RA patients.
RA is now established as an independent cardiovascular risk factor, while
mechanistic determinants of ED in RA are still poorly understood. An expanding
body of study has shown that EC at a site of RA is both active participant and
regulator of inflammatory process. Over the last decade, a role for endothelial
dysfunction in RA associated with cardiovascular disease (CVD) has been
hypothesized. At the same time, several maintenance drugs targeting this
phenomenon have been tested, which has promising results. Assessment of
endothelial function may be a useful tool to identify and monitor RA patients.
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