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10.1038/nrm3440

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suck abstract from ncbi


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pmid22992592      Nat+Rev+Mol+Cell+Biol 2012 ; 13 (10): 607-25
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  • Endoplasmic reticulum?mitochondria contacts: function of the junction #MMPMID22992592
  • Rowland AA; Voeltz GK
  • Nat Rev Mol Cell Biol 2012[Oct]; 13 (10): 607-25 PMID22992592show ga
  • The most well-characterized organelle contact sites are those between the endoplasmic reticulum (ER) and mitochondria. Increased understanding is being gained of how ER?mitochondria contact sites are organized and which factors converge at this interface, some of which may provide a tethering function. The role of the ER?mitochondria junction in coordinating the functions of these two organelles is also becoming clearer, and it has been shown to be involved in the regulation of lipid synthesis, Ca2+ signalling and the control of mitochondrial biogenesis and intracellular trafficking.
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