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Endoplasmic Reticulum Malfunction in the Nervous System
#MMPMID28487627
Jung J
; Michalak M
; Agellon LB
Front Neurosci
2017[]; 11
(?): 220
PMID28487627
show ga
Neurodegenerative diseases often have multifactorial causes and are progressive
diseases. Some are inherited while others are acquired, and both vary greatly in
onset and severity. Impaired endoplasmic reticulum (ER) proteostasis, involving
Ca(2+) signaling, protein synthesis, processing, trafficking, and degradation, is
now recognized as a key risk factor in the pathogenesis of neurological
disorders. Lipidostasis involves lipid synthesis, quality control, membrane
assembly as well as sequestration of excess lipids or degradation of damaged
lipids. Proteostasis and lipidostasis are maintained by interconnected pathways
within the cellular reticular network, which includes the ER and Ca(2+)
signaling. Importantly, lipidostasis is important in the maintenance of membranes
and luminal environment that enable optimal protein processing. Accumulating
evidence suggest that the loss of coordinate regulation of proteostasis and
lipidostasis has a direct and negative impact on the health of the nervous
system.
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