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2015 ; 7
(ä): 595-603
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English Wikipedia
Endometriosis: alternative methods of medical treatment
#MMPMID26089705
Muñoz-Hernando L
; Muñoz-Gonzalez JL
; Marqueta-Marques L
; Alvarez-Conejo C
; Tejerizo-García Á
; Lopez-Gonzalez G
; Villegas-Muñoz E
; Martin-Jimenez A
; Jiménez-López JS
Int J Womens Health
2015[]; 7
(ä): 595-603
PMID26089705
show ga
Endometriosis is an inflammatory estrogen-dependent disease defined by the
presence of endometrial glands and stroma at extrauterine sites. The main purpose
of endometriosis management is alleviating pain associated to the disease. This
can be achieved surgically or medically, although in most women a combination of
both treatments is required. Long-term medical treatment is usually needed in
most women. Unfortunately, in most cases, pain symptoms recur between 6 months
and 12 months once treatment is stopped. The authors conducted a literature
search for English original articles, related to new medical treatments of
endometriosis in humans, including articles published in PubMed, Medline, and the
Cochrane Library. Keywords included "endometriosis" matched with "medical
treatment", "new treatment", "GnRH antagonists", "Aromatase inhibitors",
"selective progesterone receptor modulators", "anti-TNF ?", and "anti-angiogenic
factors". Hormonal treatments currently available are effective in the relief of
pain associated to endometriosis. Among new hormonal drugs, association to
aromatase inhibitors could be effective in the treatment of women who do not
respond to conventional therapies. GnRH antagonists are expected to be as
effective as GnRH agonists, but with easier administration (oral). There is a
need to find effective treatments that do not block the ovarian function. For
this purpose, antiangiogenic factors could be important components of
endometriosis therapy in the future. Upcoming researches and controlled clinical
trials should focus on these drugs.