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2014 ; ä (ä): 1-49
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Endogenous RNAi pathways in C elegans
#MMPMID24816713
Billi AC
; Fischer SE
; Kim JK
WormBook
2014[May]; ä (ä): 1-49
PMID24816713
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In addition to several hundred microRNAs, C. elegans produces thousands of other
small RNAs targeting coding genes, pseudogenes, transposons, and other noncoding
RNAs. Here we review what is currently known about these endogenous small
interfering RNAs (siRNAs) and piwi-interacting RNAs (piRNAs), providing an
overview of their biogenesis, their associated protein factors, and their effects
on mRNA dynamics and chromatin structure. Additionally, we describe how the
molecular actions of these classes of endogenous small RNAs connect to their
physiological roles in the organism.