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Endogenous Ouabain: Recent Advances and Controversies #MMPMID27456525
Hamlyn JM; Blaustein MP
Hypertension 2016[Sep]; 68 (3): 526-32 PMID27456525show ga
In this brief article, we summarize recent reports about endogenous ouabain (EO), a cardiotonic steroid (CTS). This includes analysis of mammalian EO, the discovery of EO isomers, regulation of intracellular signaling by EO, and the roles of EO in hypertension, pregnancy, and heart and kidney diseases. Novel ouabain-resistant mice that elucidate the key roles of ?2 Na+ pumps and their CTS binding site are also discussed.