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2017 ; 5
(ä): 32
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Endocytic Trafficking at the Mature Podocyte Slit Diaphragm
#MMPMID28286744
Swiatecka-Urban A
Front Pediatr
2017[]; 5
(ä): 32
PMID28286744
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Endocytic trafficking couples cell signaling with the cytoskeletal dynamics by
organizing a crosstalk between protein networks in different subcellular
compartments. Proteins residing in the plasma membrane are internalized and
transported as cargo in endocytic vesicles (i.e., endocytosis). Subsequently,
cargo proteins can be delivered to lysosomes for degradation or recycled back to
the plasma membrane. The slit diaphragm is a modified tight junction connecting
foot processes of the glomerular epithelial cells, podocytes. Signaling at the
slit diaphragm plays a critical role in the kidney while its dysfunction leads to
glomerular protein loss (proteinuria), manifesting as nephrotic syndrome, a rare
condition with an estimated incidence of 2-4 new cases per 100,000 each year.
Relatively little is known about the role of endocytic trafficking in podocyte
signaling and maintenance of the slit diaphragm integrity. This review will focus
on the role of endocytic trafficking at the mature podocyte slit diaphragm.