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2015 ; 7
(4
): 253-9
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Endocrinologic Consequences of Pediatric Posterior Fossa Tumours
#MMPMID26777035
Bereket A
J Clin Res Pediatr Endocrinol
2015[Dec]; 7
(4
): 253-9
PMID26777035
show ga
Intracranial tumors are the second most frequent malignancies in children and
posterior fossa is a common location for these neoplasias during childhood.
Recent advances in surgical techniques, radiotherapy and chemotherapy resulted in
dramatic increase in the survival rates of these children, however they are still
source of a significant morbidity and mortality. Endocrinological complications
and late sequelae of childhood posterior fossa tumours are common among the
survivors of these tumours and include growth retardation, hypothyroidism,
pubertal disorders, gonadal dysfunction and osteopenia. These complications have
significant impact on the quality of life of the survivors of childhood posterior
fossa tumours. In this paper, the frequency, etiology, and management of these
complications will be reviewed.