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2017 ; 8
(ä): 134
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Endocrine Disruption of Vasopressin Systems and Related Behaviors
#MMPMID28674520
Patisaul HB
Front Endocrinol (Lausanne)
2017[]; 8
(ä): 134
PMID28674520
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Endocrine disrupting chemicals (EDCs) are chemicals that interfere with the
organizational or activational effects of hormones. Although the vast majority of
the EDC literature focuses on steroid hormone signaling related impacts, growing
evidence from a myriad of species reveals that the nonapeptide hormones
vasopressin (AVP) and oxytocin (OT) may also be EDC targets. EDCs shown to alter
pathways and behaviors coordinated by AVP and/or OT include the plastics
component bisphenol A (BPA), the soy phytoestrogen genistein (GEN), and various
flame retardants. Many effects are sex specific and likely involve action at
nuclear estrogen receptors. Effects include the elimination or reversal of
well-characterized sexually dimorphic aspects of the AVP system, including
innervation of the lateral septum and other brain regions critical for social and
other non-reproductive behaviors. Disruption of magnocellular AVP function has
also been reported in rats, suggesting possible effects on hemodynamics and
cardiovascular function.