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2016 ; 17
(2
): 230
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Endocannabinoids as Guardians of Metastasis
#MMPMID26875980
Tegeder I
Int J Mol Sci
2016[Feb]; 17
(2
): 230
PMID26875980
show ga
Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in
cancer pathophysiology in several ways, including tumor growth and progression,
peritumoral inflammation, nausea and cancer pain. Recently we showed that the
endocannabinoid profiles are deranged during cancer to an extent that this
manifests in alterations of plasma endocannabinoids in cancer patients, which was
mimicked by similar changes in rodent models of local and metastatic cancer. The
present topical review summarizes the complexity of endocannabinoid signaling in
the context of tumor growth and metastasis.
|Animals
[MESH]
|Antineoplastic Agents/pharmacology/therapeutic use
[MESH]