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2015 ; 144
(3
): 352-364
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Endocannabinoid signalling in innate and adaptive immunity
#MMPMID25585882
Chiurchił V
; Battistini L
; Maccarrone M
Immunology
2015[Mar]; 144
(3
): 352-364
PMID25585882
show ga
The immune system can be modulated and regulated not only by foreign antigens but
also by other humoral factors and metabolic products, which are able to affect
several quantitative and qualitative aspects of immunity. Among these,
endocannabinoids are a group of bioactive lipids that might serve as secondary
modulators, which when mobilized coincident with or shortly after first-line
immune modulators, increase or decrease many immune functions. Most immune cells
express these bioactive lipids, together with their set of receptors and of
enzymes regulating their synthesis and degradation. In this review, a synopsis of
the manifold immunomodulatory effects of endocannabinoids and their signalling in
the different cell populations of innate and adaptive immunity is appointed, with
a particular distinction between mice and human immune system compartments.