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2017 ; 40
(7
): 385-396
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Endocannabinoid Signaling in the Control of Social Behavior
#MMPMID28554687
Wei D
; Allsop S
; Tye K
; Piomelli D
Trends Neurosci
2017[Jul]; 40
(7
): 385-396
PMID28554687
show ga
Many mammalian species, including humans, exhibit social behavior and form
complex social groups. Mechanistic studies in animal models have revealed
important roles for the endocannabinoid signaling system, comprising G
protein-coupled cannabinoid receptors and their endogenous lipid-derived
agonists, in the control of neural processes that underpin social anxiety and
social reward, two key aspects of social behavior. An emergent insight from these
studies is that endocannabinoid signaling in specific circuits of the brain is
context dependent and selectively recruited. These insights open new vistas on
the neural basis of social behavior and social impairment.