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10.1101/gr.190124.115 http://scihub22266oqcxt.onion/10.1101/gr.190124.115 C4579329!4579329 !26430154     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26430154 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26430154 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genome+Res 2015 ; 25 (10 ): 1442-55 Nephropedia Template TP {{tp|p=26430154 |t=2015. Enabling functional genomics with genome engineering |pdf=|usr=}}{{26430154 }} gab.com Text Enabling functional genomics with genome engineering JO: Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=26430154 #FOAvip Advances in genome engineering technologies have made the precise control over genome sequence and regulation possible across a variety of disciplines. These tools can expand our understanding of fundamental biological processes and create new opportunities for therapeutic designs. The rapid evolution of these methods has also catalyzed a new era of genomics that includes multiple approaches to functionally characterize and manipulate the regulation of genomic information. Here, we review the recent advances of the most widely adopted genome engineering platforms and their application to functional genomics. This includes engineered zinc finger proteins, TALEs/TALENs, and the CRISPR/Cas9 system as nucleases for genome editing, transcription factors for epigenome editing, and other emerging applications. We also present current and potential future applications of these tools, as well as their current limitations and areas for future advances. Twit Text FOAVip Enabling functional genomics with genome engineering ????Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=26430154 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26430154 #FOAvip English Wikipedia <ref>{{Cite pmid|26430154 }}</ref> Enabling functional genomics with genome engineering #MMPMID26430154 Hilton IB ; Gersbach CA Genome Res 2015[Oct]; 25 (10 ): 1442-55 PMID26430154 show ga Advances in genome engineering technologies have made the precise control over genome sequence and regulation possible across a variety of disciplines. These tools can expand our understanding of fundamental biological processes and create new opportunities for therapeutic designs. The rapid evolution of these methods has also catalyzed a new era of genomics that includes multiple approaches to functionally characterize and manipulate the regulation of genomic information. Here, we review the recent advances of the most widely adopted genome engineering platforms and their application to functional genomics. This includes engineered zinc finger proteins, TALEs/TALENs, and the CRISPR/Cas9 system as nucleases for genome editing, transcription factors for epigenome editing, and other emerging applications. We also present current and potential future applications of these tools, as well as their current limitations and areas for future advances. |*Genetic Engineering [MESH] |*Genomics [MESH] |Animals [MESH] |Clustered Regularly Interspaced Short Palindromic Repeats [MESH] |Genetic Techniques [MESH] |Humans [MESH] |Transcriptional Activation [MESH]Enabling functional genomics with genome engineering (epmc).pdf DeepDyve Pubget Overpricing