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2019 ; 196
(2
): 157-166
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Emerging viruses and current strategies for vaccine intervention
#MMPMID30993690
Afrough B
; Dowall S
; Hewson R
Clin Exp Immunol
2019[May]; 196
(2
): 157-166
PMID30993690
show ga
During the past decade several notable viruses have suddenly emerged from
obscurity or anonymity to become serious global health threats, provoking concern
regarding their sustained epidemic transmission in immunologically naive human
populations. With each new threat comes the call for rapid vaccine development.
Indeed, vaccines are considered a critical component of disease prevention for
emerging viral infections because, in many cases, other medical options are
limited or non-existent, or that infections result in such a rapid clinical
deterioration that the effectiveness of therapeutics is limited. While classic
approaches to vaccine development are still amenable to emerging viruses, the
application of molecular techniques in virology has profoundly influenced our
understanding of virus biology, and vaccination methods based on replicating,
attenuated and non-replicating virus vector approaches have become useful vaccine
platforms. Together with a growing understanding of viral disease emergence, a
range of vaccine strategies and international commitment to underpin development,
vaccine intervention for new and emerging viruses may become a possibility.
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