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10.1093/brain/aww081 http://scihub22266oqcxt.onion/10.1093/brain/aww081 C4892756!4892756 !27190030     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27190030 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27190030 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Brain 2016 ; 139 (Pt 6 ): 1633-48 Nephropedia Template TP {{tp|p=27190030 |t=2016. Emerging therapies for mitochondrial disorders |pdf=|usr=}}{{27190030 }} gab.com Text Emerging therapies for mitochondrial disorders JO: Brain http://www.kidney.de/pget.php?&tw=1&pmid=27190030 #FOAvip Mitochondrial disorders are a diverse group of debilitating conditions resulting from nuclear and mitochondrial DNA mutations that affect multiple organs, often including the central and peripheral nervous system. Despite major advances in our understanding of the molecular mechanisms, effective treatments have not been forthcoming. For over five decades patients have been treated with different vitamins, co-factors and nutritional supplements, but with no proven benefit. There is therefore a clear need for a new approach. Several new strategies have been proposed acting at the molecular or cellular level. Whilst many show promise in vitro, the clinical potential of some is questionable. Here we critically appraise the most promising preclinical developments, placing the greatest emphasis on diseases caused by mitochondrial DNA mutations. With new animal and cellular models, longitudinal deep phenotyping in large patient cohorts, and growing interest from the pharmaceutical industry, the field is poised to make a breakthrough. Twit Text FOAVip Emerging therapies for mitochondrial disorders ????Brain http://www.kidney.de/pget.php?&tw=1&pmid=27190030 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27190030 #FOAvip English Wikipedia <ref>{{Cite pmid|27190030 }}</ref> Emerging therapies for mitochondrial disorders #MMPMID27190030 Nightingale H ; Pfeffer G ; Bargiela D ; Horvath R ; Chinnery PF Brain 2016[Jun]; 139 (Pt 6 ): 1633-48 PMID27190030 show ga Mitochondrial disorders are a diverse group of debilitating conditions resulting from nuclear and mitochondrial DNA mutations that affect multiple organs, often including the central and peripheral nervous system. Despite major advances in our understanding of the molecular mechanisms, effective treatments have not been forthcoming. For over five decades patients have been treated with different vitamins, co-factors and nutritional supplements, but with no proven benefit. There is therefore a clear need for a new approach. Several new strategies have been proposed acting at the molecular or cellular level. Whilst many show promise in vitro, the clinical potential of some is questionable. Here we critically appraise the most promising preclinical developments, placing the greatest emphasis on diseases caused by mitochondrial DNA mutations. With new animal and cellular models, longitudinal deep phenotyping in large patient cohorts, and growing interest from the pharmaceutical industry, the field is poised to make a breakthrough. |Animals [MESH] |DNA, Mitochondrial/genetics [MESH] |Disease Models, Animal [MESH] |Drug Delivery Systems/methods [MESH] |Humans [MESH] |Mitochondrial Diseases/*drug therapy/genetics/surgery [MESH] |Models, Biological [MESH] |Molecular Targeted Therapy/*methods [MESH] |Mutation [MESH]Emerging therapies for mitochondrial disorders (epmc).pdf DeepDyve Pubget Overpricing