Emerging themes of regulation at the Golgi
#MMPMID28213314
Makowski SL
; Tran TT
; Field SJ
Curr Opin Cell Biol
2017[Apr]; 45
(?): 17-23
PMID28213314
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The Golgi is generally recognized for its central role in the secretory pathway
to orchestrate protein post-translational modification and trafficking of
proteins and lipids to their final destination. Despite the common view of the
Golgi as an inert sorting organelle, emerging data demonstrate that important
signaling events occur at the Golgi, including those that regulate the
trafficking function of the Golgi. The
phosphatidylinositol-4-phosphate/GOLPH3/MYO18A/F-actin complex serves as a hub
for signals that regulate Golgi trafficking function. Furthermore, the Golgi is
increasingly appreciated for its important role in cell growth and in driving
oncogenic transformation, as illuminated by the discovery that GOLPH3 and MYO18A
are cancer drivers.
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