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10.1208/s12248-014-9682-8 http://scihub22266oqcxt.onion/10.1208/s12248-014-9682-8 C4287293!4287293 !25331105     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25331105 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       AAPS+J 2015 ; 17 (1 ): 93-101 Nephropedia Template TP {{tp|p=25331105 |t=2015. Emerging technologies to increase ligand binding assay sensitivity |pdf=|usr=}}{{25331105 }} gab.com Text Emerging technologies to increase ligand binding assay sensitivity JO: AAPS J http://www.kidney.de/pget.php?&tw=1&pmid=25331105 #FOAvip Ligand binding assays (LBAs) have been the method of choice for protein analyte measurements for more than four decades. Over the years, LBA methods have improved in sensitivity and achieved larger dynamic ranges by using alternative detection systems and new technologies. As a consequence, the landscape and application of immunoassay platforms has changed dramatically. The introduction of bead-based methods, coupled with single molecule detection standardization and the ability to amplify assay signals, has improved the sensitivity of many immunoassays, in some cases by several logs of magnitude. Three promising immunoassay platforms are described in this article: Single Molecule Counting (SMC?) from Singulex Inc, Single Molecule Arrays (Simoa?) from Quanterix Corporation, and Immuno-PCR (Imperacer®) from Chimera Biotec GmbH. These platforms have the potential to significantly improve immunoassay sensitivity and thereby address the bioanalytical needs and challenges faced during biopharmaceutical drug development. Twit Text FOAVip Emerging technologies to increase ligand binding assay sensitivity ????AAPS J http://www.kidney.de/pget.php?&tw=1&pmid=25331105 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25331105 #FOAvip English Wikipedia <ref>{{Cite pmid|25331105 }}</ref> Emerging technologies to increase ligand binding assay sensitivity #MMPMID25331105 Fischer SK ; Joyce A ; Spengler M ; Yang TY ; Zhuang Y ; Fjording MS ; Mikulskis A AAPS J 2015[Jan]; 17 (1 ): 93-101 PMID25331105 show ga Ligand binding assays (LBAs) have been the method of choice for protein analyte measurements for more than four decades. Over the years, LBA methods have improved in sensitivity and achieved larger dynamic ranges by using alternative detection systems and new technologies. As a consequence, the landscape and application of immunoassay platforms has changed dramatically. The introduction of bead-based methods, coupled with single molecule detection standardization and the ability to amplify assay signals, has improved the sensitivity of many immunoassays, in some cases by several logs of magnitude. Three promising immunoassay platforms are described in this article: Single Molecule Counting (SMC?) from Singulex Inc, Single Molecule Arrays (Simoa?) from Quanterix Corporation, and Immuno-PCR (Imperacer®) from Chimera Biotec GmbH. These platforms have the potential to significantly improve immunoassay sensitivity and thereby address the bioanalytical needs and challenges faced during biopharmaceutical drug development. |*Drug Design [MESH] |Humans [MESH] |Immunoassay/*methods [MESH] |Ligands [MESH] |Proteins/*analysis [MESH]Emerging technologies to increase ligand binding assay sensitivity (epmc).pdf DeepDyve Pubget Overpricing