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2014 ; 27
(4
): 783-822
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Emerging technologies for the clinical microbiology laboratory
#MMPMID25278575
Buchan BW
; Ledeboer NA
Clin Microbiol Rev
2014[Oct]; 27
(4
): 783-822
PMID25278575
show ga
In this review we examine the literature related to emerging technologies that
will help to reshape the clinical microbiology laboratory. These topics include
nucleic acid amplification tests such as isothermal and point-of-care molecular
diagnostics, multiplexed panels for syndromic diagnosis, digital PCR,
next-generation sequencing, and automation of molecular tests. We also review
matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) and
electrospray ionization (ESI) mass spectrometry methods and their role in
identification of microorganisms. Lastly, we review the shift to liquid-based
microbiology and the integration of partial and full laboratory automation that
are beginning to impact the clinical microbiology laboratory.