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2016 ; 1374
(1
): 123-31
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Emerging targets for treating sulfur mustard-induced injuries
#MMPMID27285828
Ahmad S
; Ahmad A
Ann N Y Acad Sci
2016[Jun]; 1374
(1
): 123-31
PMID27285828
show ga
Sulfur mustard (SM; bis-(2-chlororethyl) sulfide) is a highly reactive, potent
warfare agent that has recently reemerged as a major threat to military and
civilians. Exposure to SM is often fatal, primarily due to pulmonary injuries and
complications caused by its inhalation. Profound inflammation, hypercoagulation,
and oxidative stress are the hallmarks that define SM-induced pulmonary
toxicities. Despite advances, effective therapies are still limited. This current
review focuses on inflammatory and coagulation pathways that influence the airway
pathophysiology of SM poisoning and highlights the complexity of developing an
effective therapeutic target.