Emerging strategies to effectively target autophagy in cancer
#MMPMID25893285
Rebecca VW
; Amaravadi RK
Oncogene
2016[Jan]; 35
(1
): 1-11
PMID25893285
show ga
Autophagy serves a dichotomous role in cancer and recent advances have helped
delineate the appropriate settings where inhibiting or promoting autophagy may
confer therapeutic efficacy in patients. Our evolving understanding of the
molecular machinery responsible for the tightly controlled regulation of this
homeostatic mechanism has begun to bear fruit in the way of autophagy-oriented
clinical trials and promising lead compounds to modulate autophagy for
therapeutic benefit. In this manuscript we review the recent preclinical and
clinical therapeutic strategies that involve autophagy modulation in cancer.
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