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Emerging roles for LPP in metastatic cancer progression
#MMPMID29027626
Ngan E
; Kiepas A
; Brown CM
; Siegel PM
J Cell Commun Signal
2018[Mar]; 12
(1
): 143-156
PMID29027626
show ga
LIM domain containing proteins are important regulators of diverse cellular
processes, and play pivotal roles in regulating the actin cytoskeleton. Lipoma
Preferred Partner (LPP) is a member of the zyxin family of LIM proteins that has
long been characterized as a promoter of mesenchymal/fibroblast cell migration.
More recently, LPP has emerged as a critical inducer of tumor cell migration,
invasion and metastasis. LPP is thought to contribute to these malignant
phenotypes by virtue of its ability to shuttle into the nucleus, localize to
adhesions and, most recently, to promote invadopodia formation. In this review,
we will examine the mechanisms through which LPP regulates the functions of
adhesions and invadopodia, and discuss potential roles of LPP in mediating
cellular responses to mechanical cues within these mechanosensory structures.
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