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10.1097/MOG.0000000000000352 http://scihub22266oqcxt.onion/10.1097/MOG.0000000000000352 C5646688!5646688 !28257308     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28257308 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28257308 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Gastroenterol 2017 ; 33 (3 ): 149-157 Nephropedia Template TP {{tp|p=28257308 |t=2017. Emerging pharmacologic therapies for primary sclerosing cholangitis |pdf=|usr=}}{{28257308 }} gab.com Text Emerging pharmacologic therapies for primary sclerosing cholangitis JO: Curr Opin Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28257308 #FOAvip PURPOSE OF REVIEW: The only currently approved treatment for primary sclerosing cholangitis (PSC) is liver transplantation, with a median time to transplant of 12-18 years after diagnosis. There are a number of emerging drugs that have the potential to meet this critically unmet need that will be summarized and discussed herein. RECENT FINDINGS: Although the cause of PSC is unknown, there are a number of novel therapeutics under development. These drugs target presumed pathogenic mechanisms largely extrapolated from ex-vivo and in-vivo preclinical models, as well as translational observations. SUMMARY: Future therapeutic strategies for PSC may include a multitude of complex pathogenic mechanisms encompassing pathways of immunomodulation, the microbiome and inflammation-related fibrosis. Twit Text FOAVip Emerging pharmacologic therapies for primary sclerosing cholangitis ????Curr Opin Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28257308 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28257308 #FOAvip English Wikipedia <ref>{{Cite pmid|28257308 }}</ref> Emerging pharmacologic therapies for primary sclerosing cholangitis #MMPMID28257308 Cheung AC ; Lazaridis KN ; LaRusso NF ; Gores GJ Curr Opin Gastroenterol 2017[May]; 33 (3 ): 149-157 PMID28257308 show ga PURPOSE OF REVIEW: The only currently approved treatment for primary sclerosing cholangitis (PSC) is liver transplantation, with a median time to transplant of 12-18 years after diagnosis. There are a number of emerging drugs that have the potential to meet this critically unmet need that will be summarized and discussed herein. RECENT FINDINGS: Although the cause of PSC is unknown, there are a number of novel therapeutics under development. These drugs target presumed pathogenic mechanisms largely extrapolated from ex-vivo and in-vivo preclinical models, as well as translational observations. SUMMARY: Future therapeutic strategies for PSC may include a multitude of complex pathogenic mechanisms encompassing pathways of immunomodulation, the microbiome and inflammation-related fibrosis. |Anti-Bacterial Agents/therapeutic use [MESH] |Chenodeoxycholic Acid/analogs & derivatives/therapeutic use [MESH] |Cholangitis, Sclerosing/*drug therapy/microbiology [MESH] |Clinical Trials as Topic/methods [MESH] |Fecal Microbiota Transplantation [MESH] |Fibric Acids/therapeutic use [MESH] |Gastrointestinal Microbiome/drug effects [MESH] |Humans [MESH] |Immunologic Factors/therapeutic use [MESH] |Molecular Targeted Therapy/*methods/trends [MESH] |Organic Anion Transporters, Sodium-Dependent/antagonists & inhibitors [MESH] |Probiotics/therapeutic use [MESH] |Symporters/antagonists & inhibitors [MESH]Emerging pharmacologic therapies for primary sclerosing cholangitis (epmc).pdf DeepDyve Pubget Overpricing