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2017 ; 29
(2
): 218-224
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Emerging exposures of developmental toxicants
#MMPMID28059904
Wolff MS
; Buckley JP
; Engel SM
; McConnell RS
; Barr DB
Curr Opin Pediatr
2017[Apr]; 29
(2
): 218-224
PMID28059904
show ga
PURPOSE OF REVIEW: The purpose of this review is to identify emerging
developmental toxicants that are understudied in children's health. Exposures may
arise from new products designed to improve utility, to reduce toxicity, or to
replace undesirable chemicals. Exposures to less-toxic chemicals may also be
significant if they are very commonly used, thereby generating widespread
exposure. Sources of exposure include the workplace, personal, home, and office
products; food, water, and air. RECENT FINDINGS: We describe eight exposure
categories that contain numerous potential developmental toxicants. References
are discussed if reported in PubMed during the past decade at least 10 times more
frequently than in 1990-2000. Examples included phthalates, phenols, sunscreens,
pesticides, halogenated flame retardants, perfluoroalkyl coatings, nanoparticles,
e-cigarettes, and dietary polyphenols. Replacements are often close structural
homologs of their precursors. We suggest biomonitoring as preferred means of
exposure assessment to emerging chemicals. Some existing analytic methods would
require minimal modification to measure these exposures, but others require
toxicokinetic and analytic investigation. SUMMARY: A deliberate strategy for
biomonitoring of emerging replacement chemicals is warranted, especially in view
of concerns regarding developmental toxicity. To prevent adverse health effects,
it is important to characterize such exposures before they become widely
disseminated.
|*Environmental Health
[MESH]
|Electronic Nicotine Delivery Systems/statistics & numerical data
[MESH]
|Environmental Exposure/*adverse effects/*prevention & control/statistics &
numerical data
[MESH]
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