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2014 ; 57
(12
): 718-33
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Emerging drugs and vaccines for candidemia
#MMPMID25294098
Moriyama B
; Gordon LA
; McCarthy M
; Henning SA
; Walsh TJ
; Penzak SR
Mycoses
2014[Dec]; 57
(12
): 718-33
PMID25294098
show ga
Candidemia and other forms of invasive candidiasis are important causes of
morbidity and mortality. The evolving challenge of antimicrobial resistance among
fungal pathogens continues to highlight the need for potent, new antifungal
agents. MEDLINE, EMBASE, Scopus and Web of Science searches (up to January 2014)
of the English-language literature were performed with the keywords 'Candida' or
'Candidemia' or 'Candidiasis' and terms describing investigational drugs with
activity against Candida spp. Conference abstracts and the bibliographies of
pertinent articles were also reviewed for relevant reports. ClinicalTrials.gov
was searched for relevant clinical trials. Currently available antifungal agents
for the treatment of candidemia are summarised. Investigational antifungal agents
with potential activity against Candida bloodstream infections and other forms of
invasive candidiasis and vaccines for prevention of Candida infections are also
reviewed as are selected antifungal agents no longer in development. Antifungal
agents currently in clinical trials include isavuconazole, albaconazole, SCY-078,
VT-1161 and T-2307. Further data are needed to determine the role of these
compounds in the treatment of candidemia and other forms of invasive candidiasis.
The progressive reduction in antimicrobial drug development may result in a
decline in antifungal drug discovery. Still, there remains a critical need for
new antifungal agents to treat and prevent invasive candidiasis and other
life-threatening mycoses.
|Antifungal Agents/*therapeutic use
[MESH]
|Candidemia/*drug therapy/*prevention & control
[MESH]
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