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10.1042/BST20150045 http://scihub22266oqcxt.onion/10.1042/BST20150045 C4824043!4824043 !26009197     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26009197 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26009197 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochem+Soc+Trans 2015 ; 43 (3 ): 495-501 Nephropedia Template TP {{tp|p=26009197 |t=2015. Emerging concepts regarding pannexin 1 in the vasculature |pdf=|usr=}}{{26009197 }} gab.com Text Emerging concepts regarding pannexin 1 in the vasculature JO: Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=26009197 #FOAvip Pannexin channels are newly discovered ATP release channels expressed throughout the body. Pannexin 1 (Panx1) channels have become of great interest as they appear to participate in a multitude of signalling cascades, including regulation of vascular function. Although numerous Panx1 pharmacological inhibitors have been discovered, these inhibitors are not specific for Panx1 and have additional effects on other proteins. Therefore, molecular tools, such as RNA interference and knockout animals, are needed to demonstrate the role of pannexins in various cellular functions. This review focuses on the known roles of Panx1 related to purinergic signalling in the vasculature focusing on post-translational modifications and channel gating mechanisms that may participate in the regulated release of ATP. Twit Text FOAVip Emerging concepts regarding pannexin 1 in the vasculature ????Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=26009197 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26009197 #FOAvip English Wikipedia <ref>{{Cite pmid|26009197 }}</ref> Emerging concepts regarding pannexin 1 in the vasculature #MMPMID26009197 Good ME ; Begandt D ; DeLalio LJ ; Keller AS ; Billaud M ; Isakson BE Biochem Soc Trans 2015[Jun]; 43 (3 ): 495-501 PMID26009197 show ga Pannexin channels are newly discovered ATP release channels expressed throughout the body. Pannexin 1 (Panx1) channels have become of great interest as they appear to participate in a multitude of signalling cascades, including regulation of vascular function. Although numerous Panx1 pharmacological inhibitors have been discovered, these inhibitors are not specific for Panx1 and have additional effects on other proteins. Therefore, molecular tools, such as RNA interference and knockout animals, are needed to demonstrate the role of pannexins in various cellular functions. This review focuses on the known roles of Panx1 related to purinergic signalling in the vasculature focusing on post-translational modifications and channel gating mechanisms that may participate in the regulated release of ATP. |Adenosine Triphosphate/metabolism [MESH] |Animals [MESH] |Connexins/*genetics/metabolism [MESH] |Humans [MESH] |Muscle, Smooth, Vascular/growth & development/*metabolism [MESH] |Nerve Tissue Proteins/*genetics/metabolism [MESH] |Protein Processing, Post-Translational/*genetics [MESH] |RNA Interference [MESH] |Receptors, Purinergic/genetics/*metabolism [MESH]Emerging concepts regarding pannexin 1 in the vasculature (epmc).pdf DeepDyve Pubget Overpricing