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2015 ; 6
(ä): 317
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Emerging and Novel Functions of Complement Protein C1q
#MMPMID26175731
Kouser L
; Madhukaran SP
; Shastri A
; Saraon A
; Ferluga J
; Al-Mozaini M
; Kishore U
Front Immunol
2015[]; 6
(ä): 317
PMID26175731
show ga
Complement protein C1q, the recognition molecule of the classical pathway,
performs a diverse range of complement and non-complement functions. It can bind
various ligands derived from self, non-self, and altered self and modulate the
functions of immune and non-immune cells including dendritic cells and microglia.
C1q involvement in the clearance of apoptotic cells and subsequent B cell
tolerance is more established now. Recent evidence appears to suggest that C1q
plays an important role in pregnancy where its deficiency and dysregulation can
have adverse effects, leading to preeclampsia, missed abortion, miscarriage or
spontaneous loss, and various infections. C1q is also produced locally in the
central nervous system, and has a protective role against pathogens and possible
inflammatory functions while interacting with aggregated proteins leading to
neurodegenerative diseases. C1q role in synaptic pruning, and thus CNS
development, its anti-cancer effects as an immune surveillance molecule, and
possibly in aging are currently areas of extensive research.