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2014 ; 2
(4
): ä Nephropedia Template TP
gab.com Text
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English Wikipedia
Emerging Roles for Platelets in Inflammation and Disease
#MMPMID28758142
Ferrer-Acosta Y
; González M
; Fernández M
; Valance WA
J Infect Dis Ther
2014[Aug]; 2
(4
): ä PMID28758142
show ga
Platelets and their interaction with cells of the immune system contribute
through a variety of molecular mechanisms to support hemostasis and inflammation.
These simple yet essential cells exert their effects in lymphocytes, monocytes,
and neutrophils, both recruiting and modulating their function after activation.
Emerging evidence is starting to define the mechanisms that allow platelets to
also play pivotal roles in host defense. For example, platelet cell-surface
expression of toll-like receptors allows platelets to direct neutrophil
activation toward extracellular trap formation and facilitate the elimination of
blood pathogens. In addition to these well-known receptors, two of the most
recently discovered platelet receptors, C-type lectin receptor 2 (CLEC-2), and
TREM-like transcript-1 (TLT-1), have been shown to modulate hemostatic and
inflammation-related roles in platelets. This review will discuss the evolution
of our understanding of platelet functions from hemostasis to inflammation, and
highlight novel mechanisms that platelets use to mediate hemostasis under
inflammatory pressure.