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2015 ; 7
(7
): a015784
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Emergent Properties of the Metaphase Spindle
#MMPMID26134313
Reber S
; Hyman AA
Cold Spring Harb Perspect Biol
2015[Jul]; 7
(7
): a015784
PMID26134313
show ga
A metaphase spindle is a complex structure consisting of microtubules and a
myriad of different proteins that modulate microtubule dynamics together with
chromatin and kinetochores. A decade ago, a full description of spindle formation
and function seemed a lofty goal. Here, we describe how work in the last 10 years
combining cataloging of spindle components, the characterization of their
biochemical activities using single-molecule techniques, and theory have advanced
our knowledge. Taken together, these advances suggest that a full understanding
of spindle assembly and function may soon be possible.