Emergency Room Treatment of Hypertensive Crises
#MMPMID26622081
Salkic S
; Brkic S
; Batic-Mujanovic O
; Ljuca F
; Karabasic A
; Mustafic S
Med Arch
2015[Oct]; 69
(5
): 302-6
PMID26622081
show ga
AIM: The aim of the study was to evaluate efficiency of hypertensive urgency
treatment using inhibitors of ?1-adrenergic receptors and angiotensin converting
enzyme inhibitors-ACE inhibitors in the Emergency Room of Outpatient Hospital and
Polyclinic "dr Mustafa ?ehovic" Tuzla in relation to age, duration and severity
of hypertension. METHODS: The study was conducted from June 2011 to May 2012 and
included 120 patients of both sexes diagnosed with arterial hypertension, aged 40
to 80 with verified hypertensive urgency. The patients were divided into two
groups: the control group treated with sublingual captopril and the experimental
group treated intravenously with urapidil. RESULTS: The results show that the
largest number of patients belonged to age group from 60 to 69 years (34,16%),
and the average age was 58 (11). The largest number of patients (38,0%) had
verified hypertension for 11 to 20 years. The average systolic/diastolic artery
blood pressure at reception was 213 (19) / 130 (4) mmHg. The average
systolic/diastolic artery blood pressure after the first dose of 12,5 mg
captopril in the control group was 177,42 (10,91) / 112,33 (3,50) mmHg, while
after the first dose of 12,5 mg urapidil it was 179,25 (16,62) / 110,33 (8,78)
mmHg. The average systolic/diastolic artery blood pressure after the second dose
of 12,5 mg of captopril in the control group was 152,00 (6,32) / 95,50 (3,76)
mmHg, while after the second dose of 12,5 mg of urapidil it was 152,55 (7,17) /
95,29 (5,04) mmHg. CONCLUSION: Urapidil is more efficient in hypertensive urgency
treatment, since the decrease of middle artery pressure (MAP) in the group
treated with urapidil was statistically significant (p<0,001). No statistical
significance was found between the efficiency of urapidil and the patient's age,
while captopril was more efficient in older patients (p=0,02). Also, no
statistically significant difference was found between the efficiency of
captopril and urapidil in relation to duration of hypertension.
|*Emergency Service, Hospital
[MESH]
|Acute Disease
[MESH]
|Administration, Intravenous
[MESH]
|Administration, Sublingual
[MESH]
|Adrenergic alpha-1 Receptor Antagonists/*therapeutic use
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
[MESH]
|Antihypertensive Agents/*therapeutic use
[MESH]
|Blood Pressure/drug effects
[MESH]
|Bosnia and Herzegovina
[MESH]
|Captopril/administration & dosage/*therapeutic use
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Hypertension/*drug therapy
[MESH]
|Male
[MESH]
|Middle Aged
[MESH]
|Piperazines/administration & dosage/*therapeutic use
[MESH]
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