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2013 ; 3
(10
): a013847
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Embryonic heart progenitors and cardiogenesis
#MMPMID24086063
Brade T
; Pane LS
; Moretti A
; Chien KR
; Laugwitz KL
Cold Spring Harb Perspect Med
2013[Oct]; 3
(10
): a013847
PMID24086063
show ga
The mammalian heart is a highly specialized organ, comprised of many different
cell types arising from distinct embryonic progenitor populations during
cardiogenesis. Three precursor populations have been identified to contribute to
different myocytic and nonmyocytic cell lineages of the heart: cardiogenic
mesoderm cells (CMC), the proepicardium (PE), and cardiac neural crest cells
(CNCCs). This review will focus on molecular cues necessary for proper induction,
expansion, and lineage-specific differentiation of these progenitor populations
during cardiac development in vivo. Moreover, we will briefly discuss how the
knowledge gained on embryonic heart progenitor biology can be used to develop
novel therapeutic strategies for the management of congenital heart disease as
well as for improvement of cardiac function in ischemic heart disease.
free
free
free
