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2015 ; 156
(6
): 1941-51
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Elucidating the links between endocrine disruptors and neurodevelopment
#MMPMID25714811
Schug TT
; Blawas AM
; Gray K
; Heindel JJ
; Lawler CP
Endocrinology
2015[Jun]; 156
(6
): 1941-51
PMID25714811
show ga
Recent data indicate that approximately 12% of children in the United States are
affected by neurodevelopmental disorders, including attention deficit
hyperactivity disorder, learning disorders, intellectual disabilities, and autism
spectrum disorders. Accumulating evidence indicates a multifactorial etiology for
these disorders, with social, physical, genetic susceptibility, nutritional
factors, and chemical toxicants acting together to influence risk. Exposure to
endocrine-disrupting chemicals during the early stages of life can disrupt normal
patterns of development and thus alter brain function and disease susceptibility
later in life. This article highlights research efforts and pinpoints approaches
that could shed light on the possible associations between environmental
chemicals that act on the endocrine system and compromised neurodevelopmental
outcomes.