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pmid29119048
      Am+J+Cancer+Res 2017 ; 7 (10 ): 1990-1995
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  • Elucidating immunometabolic targets in glioblastoma #MMPMID29119048
  • Agarwal P ; Pajor MJ ; Anson DM ; Guda MR ; Labak CM ; Tsung AJ ; Velpula KK
  • Am J Cancer Res 2017[]; 7 (10 ): 1990-1995 PMID29119048 show ga
  • Immunometabolism has recently emerged on the forefront of cancer research as a new avenue to potentially develop more effective and targeted treatment options. Several pathologically altered metabolic targets across various cancer types have been identified, including lactate in aerobic glycolysis; tryptophan in amino acid metabolism; and arginine in the urea cycle. Numerous advancements have improved our understanding of the dual function of these targets in influencing immune functions as an auxiliary function to their well-established metabolic role. This paper provides a comprehensive overview of immunometabolism research and attempts to provide insight into potential immunometabolic targets in glioblastoma for the purpose of future development and study of targeted therapies.
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