Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\38752003
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Exp+Vaccine+Res
2024 ; 13
(2
): 83-90
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Efficacy, immunogenicity, and safety of COVID-19 vaccines in individuals with
liver cirrhosis: a rapid review and meta-analysis
#MMPMID38752003
Salajegheh F
; Rukerd MRZ
; Nakhaie M
; Ghoreshi ZA
; Charostad J
; Arefinia N
Clin Exp Vaccine Res
2024[Apr]; 13
(2
): 83-90
PMID38752003
show ga
The emergence of coronavirus disease 2019 (COVID-19) vaccines has been a
remarkable advancement. However, the efficacy, immunogenicity, and safety of
these vaccines in individuals with liver cirrhosis require careful evaluation due
to their compromised immune status and potential interactions with underlying
liver disease. The present study aimed to evaluate the safety and efficacy of
COVID-19 vaccines in liver cirrhosis patients. In the present study, we searched
international databases, including Google Scholar, PubMed, Scopus, Embase, and
Web of Science. The search strategy was carried out by using keywords and MeSH
(Medical Subject Headings) terms. STATA ver. 15.0 (Stata Corp., USA) was used to
analyze the data statistically. The analysis was performed using the
random-effects model. We also used the chi-square test and I(2) index to
calculate heterogeneity among studies. For evaluating publication bias, Begg's
funnel plots and Egger's tests were used. A total of 4,831 liver cirrhosis
patients with COVID-19 were examined from 11 studies. The rate of hospitalization
in the patients with liver cirrhosis was 17.6% (95% confidence interval [CI],
9%-44%). The rate of fever in the patients with liver cirrhosis was 4.5% (95% CI,
0.9%-8.1%). The rate of positive neutralizing antibodies in the patients with
liver cirrhosis was 82.5% (95% CI, 69.8%-95.1%). Also, the rates of
seroconversion after the second vaccination in patients with liver cirrhosis and
the control group were 96.6% (95% CI, 92.0%-99.0%), and 99.7% (95% CI,
99.0%-100.0%), respectively. COVID-19 vaccines have demonstrated promising
efficacy, immunogenicity, and safety profiles in individuals with liver
cirrhosis, providing crucial protection against COVID-19-related complications.