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2013 ; 3
(11
): ä Nephropedia Template TP
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English Wikipedia
Effector mechanisms of rejection
#MMPMID24186491
Moreau A
; Varey E
; Anegon I
; Cuturi MC
Cold Spring Harb Perspect Med
2013[Nov]; 3
(11
): ä PMID24186491
show ga
Organ transplantation appears today to be the best alternative to replace the
loss of vital organs induced by various diseases. Transplants can, however, also
be rejected by the recipient. In this review, we provide an overview of the
mechanisms and the cells/molecules involved in acute and chronic rejections. T
cells and B cells mainly control the antigen-specific rejection and act either as
effector, regulatory, or memory cells. On the other hand, nonspecific cells such
as endothelial cells, NK cells, macrophages, or polymorphonuclear cells are also
crucial actors of transplant rejection. Last, beyond cells, the high contribution
of antibodies, chemokines, and complement molecules in graft rejection is
discussed in this article. The understanding of the different components involved
in graft rejection is essential as some of them are used in the clinic as
biomarkers to detect and quantify the level of rejection.
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