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2013 ; 6
(5
): 484-5
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Eculizumab and drug-induced haemolytic-uraemic syndrome
#MMPMID26120441
Faguer S
; Huart A
; Frémeaux-Bacchi V
; Ribes D
; Chauveau D
Clin Kidney J
2013[Oct]; 6
(5
): 484-5
PMID26120441
show ga
The monoclonal anti-C5 antibody eculizumab has been successfully tested in
atypical haemolytic-uraemic syndrome (aHUS), with or without mutations in the
regulatory proteins of the alternative pathway of the complement, and less
convincingly in enterohaemorrhagic Escherichia coli-associated HUS. Here, we
report a patient with mitomycin-C-induced HUS unresponsive to plasma exchanges.
Eculizumab infusion was followed by a dramatic improvement of haematological
parameters and renal function, suggesting a role of complement blockade in the
management of refractory, drug-related HUS.