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2015 ; 11
(11
): e1005221
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Ebolavirus Evolution: Past and Present
#MMPMID26562671
de La Vega MA
; Stein D
; Kobinger GP
PLoS Pathog
2015[]; 11
(11
): e1005221
PMID26562671
show ga
The past year has marked the most devastating Ebola outbreak the world has ever
witnessed, with over 28,000 cases and over 11,000 deaths. Ebola virus (EBOV) has
now been around for almost 50 years. In this review, we discuss past and present
outbreaks of EBOV and how those variants evolved over time. We explore and
discuss selective pressures that drive the evolution of different Ebola variants,
and how they may modify the efficacy of therapeutic treatments and vaccines
currently being developed. Finally, given the unprecedented size and spread of
the outbreak, as well as the extended period of replication in human hosts,
specific attention is given to the 2014-2015 West African outbreak variant
(Makona).