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2014 ; 13
(4
): 521-31
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Ebola virus vaccines: an overview of current approaches
#MMPMID24575870
Marzi A
; Feldmann H
Expert Rev Vaccines
2014[Apr]; 13
(4
): 521-31
PMID24575870
show ga
Ebola hemorrhagic fever is one of the most fatal viral diseases worldwide
affecting humans and nonhuman primates. Although infections only occur frequently
in Central Africa, the virus has the potential to spread globally and is
classified as a category A pathogen that could be misused as a bioterrorism
agent. As of today there is no vaccine or treatment licensed to counteract Ebola
virus infections. DNA, subunit and several viral vector approaches, replicating
and non-replicating, have been tested as potential vaccine platforms and their
protective efficacy has been evaluated in nonhuman primate models for Ebola virus
infections, which closely resemble disease progression in humans. Though these
vaccine platforms seem to confer protection through different mechanisms, several
of them are efficacious against lethal disease in nonhuman primates attesting
that vaccination against Ebola virus infections is feasible.
|Africa, Central/epidemiology
[MESH]
|Animals
[MESH]
|Disease Models, Animal
[MESH]
|Disease Transmission, Infectious/*prevention & control
[MESH]
free
free
free
