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2017 ; 35
(2
): 263-281
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Early-Onset Alzheimer Disease
#MMPMID28410659
Mendez MF
Neurol Clin
2017[May]; 35
(2
): 263-281
PMID28410659
show ga
Early-onset Alzheimer disease (EOAD), with onset in individuals younger than
65 years, although overshadowed by the more common late-onset AD (LOAD), differs
significantly from LOAD. EOAD comprises approximately 5% of AD and is associated
with delays in diagnosis, aggressive course, and age-related psychosocial needs.
One source of confusion is that a substantial percentage of EOAD are phenotypic
variants that differ from the usual memory-disordered presentation of typical AD.
The management of EOAD is similar to that for LOAD, but special emphasis should
be placed on targeting the specific cognitive areas involved and more
age-appropriate psychosocial support and education.