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10.1083/jcb.201512074 http://scihub22266oqcxt.onion/10.1083/jcb.201512074 C5021093!5021093 !27621364     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27621364 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27621364 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2016 ; 214 (6 ): 753-67 Nephropedia Template TP {{tp|p=27621364 |t=2016. Early epithelial signaling center governs tooth budding morphogenesis |pdf=|usr=}}{{27621364 }} gab.com Text Early epithelial signaling center governs tooth budding morphogenesis JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27621364 #FOAvip During organogenesis, cell fate specification and patterning are regulated by signaling centers, specialized clusters of morphogen-expressing cells. In many organs, initiation of development is marked by bud formation, but the cellular mechanisms involved are ill defined. Here, we use the mouse incisor tooth as a model to study budding morphogenesis. We show that a group of nonproliferative epithelial cells emerges in the early tooth primordium and identify these cells as a signaling center. Confocal live imaging of tissue explants revealed that although these cells reorganize dynamically, they do not reenter the cell cycle or contribute to the growing tooth bud. Instead, budding is driven by proliferation of the neighboring cells. We demonstrate that the activity of the ectodysplasin/Edar/nuclear factor ?B pathway is restricted to the signaling center, and its inactivation leads to fewer quiescent cells and a smaller bud. These data functionally link the signaling center size to organ size and imply that the early signaling center is a prerequisite for budding morphogenesis. Twit Text FOAVip Early epithelial signaling center governs tooth budding morphogenesis ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27621364 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27621364 #FOAvip English Wikipedia <ref>{{Cite pmid|27621364 }}</ref> Early epithelial signaling center governs tooth budding morphogenesis #MMPMID27621364 Ahtiainen L ; Uski I ; Thesleff I ; Mikkola ML J Cell Biol 2016[Sep]; 214 (6 ): 753-67 PMID27621364 show ga During organogenesis, cell fate specification and patterning are regulated by signaling centers, specialized clusters of morphogen-expressing cells. In many organs, initiation of development is marked by bud formation, but the cellular mechanisms involved are ill defined. Here, we use the mouse incisor tooth as a model to study budding morphogenesis. We show that a group of nonproliferative epithelial cells emerges in the early tooth primordium and identify these cells as a signaling center. Confocal live imaging of tissue explants revealed that although these cells reorganize dynamically, they do not reenter the cell cycle or contribute to the growing tooth bud. Instead, budding is driven by proliferation of the neighboring cells. We demonstrate that the activity of the ectodysplasin/Edar/nuclear factor ?B pathway is restricted to the signaling center, and its inactivation leads to fewer quiescent cells and a smaller bud. These data functionally link the signaling center size to organ size and imply that the early signaling center is a prerequisite for budding morphogenesis. |*Cell Movement [MESH] |*Cell Proliferation [MESH] |Animals [MESH] |Ectodysplasins/genetics/metabolism [MESH] |Edar Receptor/genetics/metabolism [MESH] |Epithelial Cells/metabolism/*physiology [MESH] |G1 Phase [MESH] |Gene Expression Regulation, Developmental [MESH] |Genotype [MESH] |Gestational Age [MESH] |Incisor/*embryology/metabolism [MESH] |Mice, Transgenic [MESH] |Microscopy, Confocal [MESH] |Morphogenesis [MESH] |NF-kappa B/genetics/metabolism [MESH] |Organ Size [MESH] |Phenotype [MESH]Early epithelial signaling center governs tooth budding morphogenesis (epmc).pdf DeepDyve Pubget Overpricing