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2015 ; 27
(4
): 321-31
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Early detection of pancreatic cancer
#MMPMID26361402
Kim VM
; Ahuja N
Chin J Cancer Res
2015[Aug]; 27
(4
): 321-31
PMID26361402
show ga
Pancreatic adenocarcinoma is a low-incident but highly mortal disease. It
accounts for only 3% of estimated new cancer cases each year but is currently the
fourth common cause of cancer mortality. By 2030, it is expected to be the 2(nd)
leading cause of cancer death. There is a clear need to diagnose and classify
pancreatic cancer at earlier stages in order to give patients the best chance at
a definitive cure through surgery. Three precursor lesions that distinctly lead
to pancreatic adenocarcinoma have been identified, and we have increasing
understanding the non-genetic and genetic risk factors for the disease. With
increased understanding about the risk factors, the familial patters, and
associated accumulation of genetic mutations involved in pancreatic cancer, we
know that there are mutations that occur early in the development of pancreatic
cancer and that improved genetic risk-based strategies in screening for
pancreatic cancer may be possible and successful at saving or prolonging lives.
The remaining challenge is that current standards for diagnosing pancreatic
cancer remain too invasive and too costly for widespread screening for pancreatic
cancer. Furthermore, the promises of noninvasive methods of detection such as
blood, saliva, and stool remain underdeveloped or lack robust testing. However,
significant progress has been made, and we are drawing closer to a strategy for
the screening and early detection of pancreatic cancer.