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10.3390/ijms161023195 http://scihub22266oqcxt.onion/10.3390/ijms161023195 C4632693!4632693 !26404239     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26404239 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26404239 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2015 ; 16 (10 ): 23195-209 Nephropedia Template TP {{tp|p=26404239 |t=2015. Early and Degressive Putamen Atrophy in Multiple Sclerosis |pdf=|usr=}}{{26404239 }} gab.com Text Early and Degressive Putamen Atrophy in Multiple Sclerosis JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26404239 #FOAvip Putamen atrophy and its long-term progress during disease course were recently shown in patients with multiple sclerosis (MS). Here we investigated retrospectively the time point of atrophy onset in patients with relapsing-remitting MS (RRMS). 68 patients with RRMS and 26 healthy controls (HC) were admitted to 3T MRI in a cross-sectional study. We quantitatively analyzed the putamen volume of individual patients in relation to disease duration by correcting for age and intracranial volume (ICV). Patient's relative putamen volume (RPV), expressed in percent of ICV, was significantly reduced compared to HC. Based on the correlation between RPV and age, we computed the age-corrected RPV deviation (?RPV) from HC. Patients showed significantly negative ?RPV. Interestingly, the age-corrected ?RPV depended logarithmically on disease duration: Directly after first symptom manifestation, patients already showed a reduced RPV followed by a further degressive volumetric decline. This means that atrophy progression was stronger in the first than in later years of disease. Putamen atrophy starts directly after initial symptom manifestation or even years before, and progresses in a degressive manner. Due to its important role in neurological functions, early detection of putamen atrophy seems necessary. High-resolution structural MRI allows monitoring of disease course. Twit Text FOAVip Early and Degressive Putamen Atrophy in Multiple Sclerosis ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26404239 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26404239 #FOAvip English Wikipedia <ref>{{Cite pmid|26404239 }}</ref> Early and Degressive Putamen Atrophy in Multiple Sclerosis #MMPMID26404239 Krämer J ; Meuth SG ; Tenberge JG ; Schiffler P ; Wiendl H ; Deppe M Int J Mol Sci 2015[Sep]; 16 (10 ): 23195-209 PMID26404239 show ga Putamen atrophy and its long-term progress during disease course were recently shown in patients with multiple sclerosis (MS). Here we investigated retrospectively the time point of atrophy onset in patients with relapsing-remitting MS (RRMS). 68 patients with RRMS and 26 healthy controls (HC) were admitted to 3T MRI in a cross-sectional study. We quantitatively analyzed the putamen volume of individual patients in relation to disease duration by correcting for age and intracranial volume (ICV). Patient's relative putamen volume (RPV), expressed in percent of ICV, was significantly reduced compared to HC. Based on the correlation between RPV and age, we computed the age-corrected RPV deviation (?RPV) from HC. Patients showed significantly negative ?RPV. Interestingly, the age-corrected ?RPV depended logarithmically on disease duration: Directly after first symptom manifestation, patients already showed a reduced RPV followed by a further degressive volumetric decline. This means that atrophy progression was stronger in the first than in later years of disease. Putamen atrophy starts directly after initial symptom manifestation or even years before, and progresses in a degressive manner. Due to its important role in neurological functions, early detection of putamen atrophy seems necessary. High-resolution structural MRI allows monitoring of disease course. |*Disease Progression [MESH] |Adult [MESH] |Aged [MESH] |Atrophy [MESH] |Cross-Sectional Studies [MESH] |Female [MESH] |Humans [MESH] |Imaging, Three-Dimensional [MESH] |Magnetic Resonance Imaging [MESH] |Male [MESH] |Middle Aged [MESH] |Multiple Sclerosis, Relapsing-Remitting/*pathology [MESH] |Putamen/*pathology [MESH]Early and Degressive Putamen Atrophy in Multiple Sclerosis (epmc).pdf DeepDyve Pubget Overpricing