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2016 ; 8
(5
): ä Nephropedia Template TP
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English Wikipedia
Early Bunyavirus-Host Cell Interactions
#MMPMID27213430
Albornoz A
; Hoffmann AB
; Lozach PY
; Tischler ND
Viruses
2016[May]; 8
(5
): ä PMID27213430
show ga
The Bunyaviridae is the largest family of RNA viruses, with over 350 members
worldwide. Several of these viruses cause severe diseases in livestock and
humans. With an increasing number and frequency of outbreaks, bunyaviruses
represent a growing threat to public health and agricultural productivity
globally. Yet, the receptors, cellular factors and endocytic pathways used by
these emerging pathogens to infect cells remain largely uncharacterized. The
focus of this review is on the early steps of bunyavirus infection, from virus
binding to penetration from endosomes. We address current knowledge and advances
for members from each genus in the Bunyaviridae family regarding virus receptors,
uptake, intracellular trafficking and fusion.