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10.18632/oncotarget.6198 http://scihub22266oqcxt.onion/10.18632/oncotarget.6198 C4823035!4823035 !26497210     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26497210 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26497210 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (3 ): 2284-96 Nephropedia Template TP {{tp|p=26497210 |t=2016. EZH2 in normal hematopoiesis and hematological malignancies |pdf=|usr=}}{{26497210 }} gab.com Text EZH2 in normal hematopoiesis and hematological malignancies JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26497210 #FOAvip Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2, inhibits gene expression through methylation on lysine 27 of histone H3. EZH2 regulates normal hematopoietic stem cell self-renewal and differentiation. EZH2 also controls normal B cell differentiation. EZH2 deregulation has been described in many cancer types including hematological malignancies. Specific small molecules have been recently developed to exploit the oncogenic addiction of tumor cells to EZH2. Their therapeutic potential is currently under evaluation. This review summarizes the roles of EZH2 in normal and pathologic hematological processes and recent advances in the development of EZH2 inhibitors for the personalized treatment of patients with hematological malignancies. Twit Text FOAVip EZH2 in normal hematopoiesis and hematological malignancies ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26497210 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26497210 #FOAvip English Wikipedia <ref>{{Cite pmid|26497210 }}</ref> EZH2 in normal hematopoiesis and hematological malignancies #MMPMID26497210 Herviou L ; Cavalli G ; Cartron G ; Klein B ; Moreaux J Oncotarget 2016[Jan]; 7 (3 ): 2284-96 PMID26497210 show ga Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2, inhibits gene expression through methylation on lysine 27 of histone H3. EZH2 regulates normal hematopoietic stem cell self-renewal and differentiation. EZH2 also controls normal B cell differentiation. EZH2 deregulation has been described in many cancer types including hematological malignancies. Specific small molecules have been recently developed to exploit the oncogenic addiction of tumor cells to EZH2. Their therapeutic potential is currently under evaluation. This review summarizes the roles of EZH2 in normal and pathologic hematological processes and recent advances in the development of EZH2 inhibitors for the personalized treatment of patients with hematological malignancies. |Adenosine/analogs & derivatives/pharmacology [MESH] |B-Lymphocytes/cytology [MESH] |Cell Differentiation [MESH] |Cell Proliferation [MESH] |Enhancer of Zeste Homolog 2 Protein/*antagonists & inhibitors/*metabolism [MESH] |Epigenesis, Genetic [MESH] |Ethylenediamines/pharmacology [MESH] |Gene Expression Regulation [MESH] |Hematologic Neoplasms/drug therapy/*pathology [MESH] |Hematopoiesis/*physiology [MESH] |Hematopoietic Stem Cells/*cytology [MESH] |Histones/metabolism [MESH] |Humans [MESH] |Indoles/pharmacology [MESH] |Methylation [MESH] |Polycomb Repressive Complex 2/*metabolism [MESH] |Precision Medicine [MESH] |Pyrazoles/pharmacology [MESH]EZH2 in normal hematopoiesis and hematological malignancies (epmc).pdf DeepDyve Pubget Overpricing