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2017 ; 8
(ä): 311
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E2F1, a Novel Regulator of Metabolism
#MMPMID29176962
Denechaud PD
; Fajas L
; Giralt A
Front Endocrinol (Lausanne)
2017[]; 8
(ä): 311
PMID29176962
show ga
In the past years, several lines of evidence have shown that cell cycle
regulatory proteins also can modulate metabolic processes. The transcription
factor E2F1 is a central player involved in cell cycle progression, DNA-damage
response, and apoptosis. Its crucial role in the control of cell fate has been
extensively studied and reviewed before; however, here, we focus on the
participation of E2F1 in the regulation of metabolism. We summarize recent
findings about the cell cycle-independent roles of E2F1 in various tissues that
contribute to global metabolic homeostasis and highlight that E2F1 activity is
increased during obesity. Finally, coming back to the pivotal role of E2F1 in
cancer development, we discuss how E2F1 links cell cycle progression with
different metabolic adaptations required for cell growth and survival.