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10.1038/cr.2016.35

http://scihub22266oqcxt.onion/10.1038/cr.2016.35
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C4822130!4822130 !27002219
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suck abstract from ncbi


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pmid27002219
      Cell+Res 2016 ; 26 (4 ): 423-40
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  • E2 enzymes: more than just middle men #MMPMID27002219
  • Stewart MD ; Ritterhoff T ; Klevit RE ; Brzovic PS
  • Cell Res 2016[Apr]; 26 (4 ): 423-40 PMID27002219 show ga
  • Ubiquitin-conjugating enzymes (E2s) are the central players in the trio of enzymes responsible for the attachment of ubiquitin (Ub) to cellular proteins. Humans have ?40 E2s that are involved in the transfer of Ub or Ub-like (Ubl) proteins (e.g., SUMO and NEDD8). Although the majority of E2s are only twice the size of Ub, this remarkable family of enzymes performs a variety of functional roles. In this review, we summarize common functional and structural features that define unifying themes among E2s and highlight emerging concepts in the mechanism and regulation of E2s.
  • |Animals [MESH]
  • |Gene Expression Regulation [MESH]
  • |Humans [MESH]
  • |Ubiquitin-Conjugating Enzymes/chemistry/*metabolism [MESH]


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