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2017 ; 13
(4
): 1386-1392
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Dysfunction of the thymus in mice with hypertension
#MMPMID28413482
Dai X
; Huang S
; He Z
; Wu F
; Ding R
; Chen Y
; Liang C
; Wu Z
Exp Ther Med
2017[Apr]; 13
(4
): 1386-1392
PMID28413482
show ga
The aim of this study was to evaluate thymus function in mice with hypertension.
A total of 60 C57BL/6J mice were randomized into control, sham surgery and
two-kidney, one-clip groups (n=20 in each). At 4 or 8 weeks after surgery, mice
were sacrificed, and blood, spleens, kidneys and thymuses were harvested. The
results of reverse transcription-quantitative polymerase chain reaction analysis
revealed that the mRNA levels of Forkhead box protein N1 (Foxn1) and autoimmune
regulator (AIRE) in the thymus tissue of mice from the HTN group were
significantly lower than those from the control group at 4 and 8 weeks (P<0.05).
Foxn1 and AIRE expression was also reduced in the sham surgery group at 4 weeks
after surgery, but had recovered 4 weeks later. Similar results were observed for
the expression of signal-joint T cell receptor excision circles and the
percentages of T cell subsets. The present study indicates that impaired thymus
function is associated with hypertension in mice, which suggests that thymus
function may be a novel target for the treatment of patients with hypertension.