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2015 ; 21
(40
): 11450-7
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Dysbiotic infection in the stomach
#MMPMID26523109
Iizasa H
; Ishihara S
; Richardo T
; Kanehiro Y
; Yoshiyama H
World J Gastroenterol
2015[Oct]; 21
(40
): 11450-7
PMID26523109
show ga
Microbiota in human alimentary tract plays important roles for homeostatic
maintenance of the body. Compositional difference of gut microbiota is tightly
associated with susceptibility of many diseases, including inflammatory diseases,
obesity, diabetes mellitus, cancer, and atherosclerosis. "Dysbiosis" refers to a
state of imbalance among the colonies of microorganisms within the body, which
brings abnormal increase of specific minor components and decrease in the
normally dominant species. Since stomach secrets strong acid for its digestive
role, this organ has long been thought a sterile organ. However, the discovery of
Helicobacter pylori (H. pylori) has changed the concept. This bacterium has
proven to cause gastritis, peptic ulcer, and gastric cancer. However, recent
cross-sectional studies revealed that H. pylori carriers had a decreased risk of
developing immunological diseases, such as asthma. H. pylori coinfection also
suppresses inflammatory bowel diseases. This review describes human gastric
microbiota by discussing its mutual interaction and pathogenic enrollment.
Gastric "dysbiosis" may affect host inflammatory response and play important role
for gastric pathogenesis. We will topically discuss enrollment of dysbiosis for
genesis of gastric cancer as well as for disruption of immunological homeostasis
affecting oncogenic resistance.
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